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Product Name
PTGR1 antibody
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Description
PTGR1 Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in human liver tissue, HeLa cells, human colon tissue. Observed molecular weight by Western-blot: 36 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FLJ99229 antibody; LTB4DH antibody; PGR1 antibody; PRG 1 antibody; prostaglandin reductase 1 antibody; PTGR1 antibody; ZADH3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PTGR1 recombinant protein (Accession Number: NM_012212). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:114272(PTGR1 antibody) at dilution of 1:500
IP Result of anti-PTGR1 (IP:Catalog No:114272, 4ug; Detection:Catalog No:114272 1:500) with HepG2 cells lysate 3200ug.
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Background
PTGR1(Prostaglandin reductase 1) is also named as LTB4DH(NADP-dependent leukotriene B4 12-hydroxydehydrogenase) and belongs to the NADP-dependent oxidoreductase L4BD family. It catalyses the conversion of leukotriene B4 into its biologically less reactive metabolite 12-oxo-leukotriene B4, a key step for its inactivation and it is a key oxidation step in the process of metabolic inactivation of leukotriene B(4) in various non-leukocyte tissues(PMID:8576264).
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References
- Vitturi DA, Chen CS, Woodcock SR. Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. The Journal of biological chemistry. 288(35):25626-37. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"