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PSF2 antibody

Cat.#: 114301

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Product Information

  • Product Name
    PSF2 antibody
  • Documents
  • Description
    PSF2 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HepG2 cells. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 25 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    DC5 antibody; GINS complex subunit 2 antibody; GINS2 antibody; HSPC037 antibody; Pfs2 antibody; PSF2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PSF2 recombinant protein (Accession Number: NM_016095). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:50-1:500

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114301(GINS2 antibody) at dilution of 1:500

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:114301(GINS2 antibody) at dilution of 1:500

    Immunofluorescent analysis of (10% Formaldehyde) fixed HepG2 cells using Catalog No:114301(GINS2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of (10% Formaldehyde) fixed HepG2 cells using Catalog No:114301(GINS2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    GINS2, also named as DNA replication complex GINS protein PSF2, CGI-122, DC5, or HSPC037, is a 185 amino acid protein, which belongs to the GINS2/PSF2 family. The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS2 is a part of the the GINS complex, an integral component of the replicative helicase machinery that facilitates progression of the replisome complex.
  • References
    • Jagannathan M, Nguyen T, Gallo D. A role for USP7 in DNA replication. Molecular and cellular biology. 34(1):132-45. 2014.
    • Wang JT, Xu X, Alontaga AY, Chen Y, Liu Y. Impaired p32 regulation caused by the lymphoma-prone RECQ4 mutation drives mitochondrial dysfunction. Cell reports. 7(3):848-58. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"