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Product Name
Mouse P4HB (His Tag) recombinant protein
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Description
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP (By similarity).
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Protein name
Protein disulfide-isomerase
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Protein short names
PO4HB; PDIA1; PDI; RP23-84C12.2; ERBA2L; PHDB; P4HBETA; THBP; GIT; ERP59; PO4DB; PROHB; DSI; P4HB
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Uniprot ID
P09103
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Gene Name
P4hb; Pdia1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse P4HB (NP_035162.1) (Met 1-Lys 506) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse P4HB comprises 498 amino acids and has a calculated molecular mass of 56.2 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse P4HB / ERBA2L Protein (His Tag) SDS-PAGE
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