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Product Name
PRODH antibody
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Description
PRODH Rabbit Polyclonal antibody. Positive IHC detected in human cerebellum tissue, human skeletal muscle tissue. Positive WB detected in mouse liver tissue, mouse kidney tissue. Observed molecular weight by Western-blot: 56 kDa, ,66 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
FLJ33744 antibody; HSPOX2 antibody; p53 induced gene 6 protein antibody; PIG6 antibody; POX antibody; POX2 antibody; PRODH antibody; PRODH1 antibody; PRODH2 antibody; Proline oxidase antibody; Proline oxidase 2 antibody; SCZD4 antibody; TP53I6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PRODH recombinant protein (Accession Number: NM_001368250). Purification method: Antigen Affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:114212(PRODH antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human cerebellum slide using Catalog No:114212(PRODH Antibody) at dilution of 1:50(under 10x lens)
Immunohistochemistry of paraffin-embedded human cerebellum slide using Catalog No:114212(PRODH Antibody) at dilution of 1:50(under 40x lens)
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Background
PRODH(Proline dehydrogenase 1, mitochondrial) is also named as PIG6, HSPOX2, PRODH1, PRODH2, POX, SCZD4, TP53I6 and belongs to the proline oxidase family. It is an oxidoreductase involved in the transfer of redox potential across the mitochondrial membrane and catalyzes the rate-limiting oxidation of proline to pyrroline- 5-carboxylate (P5C). High PRODH activity is sufficient to induce mitochondria-mediated apoptosis in the presence of proline. Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) and defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4). This protein has 3 isoforms produced by alternative splicing with the molecular mass of 68 kDa, 59 kDa and 56 kDa.
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