Cart 2

Presenilin-1-Specific antibody

Cat.#: 114186

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Presenilin-1-Specific antibody
  • Documents
  • Description
    Presenilin-1-Specific Rabbit Polyclonal antibody. Positive WB detected in human kidney tissue. Positive IP detected in mouse kidney tissue. Observed molecular weight by Western-blot: 53 kDa
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    AD3 antibody; FAD antibody; Presenilin-1 antibody; Protein S182 antibody; PS 1 antibody; PS1 antibody; PS1 CTF12 antibody; PSEN1 antibody; PSNL1 antibody; S182 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_000021). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

  • Validations

    human kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:114186(PSEN1-Specific antibody) at dilution of 1:600

    human kidney tissue were subjected to SDS PAGE followed by western blot with Catalog No:114186(PSEN1-Specific antibody) at dilution of 1:600

    IP Result of anti-PSEN1-Specific (IP:Catalog No:114186, 4ug; Detection:Catalog No:114186 1:1000) with mouse kidney tissue lysate 4000ug.

    IP Result of anti-PSEN1-Specific (IP:Catalog No:114186, 4ug; Detection:Catalog No:114186 1:1000) with mouse kidney tissue lysate 4000ug.

  • Background
    PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome(PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.
  • References
    • Cai D, Yuan M, Jia Y, Liu H, Hu Y, Zhao R. Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway. The Journal of nutritional biochemistry. 26(12):1622-31. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"