PRAME antibody

PRAME antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PRAME Rabbit Polyclonal antibody. Positive IP detected in A549 cells. Positive WB detected in A549 cells, HepG2 cells. Observed molecular weight by Western-blot: 58 kDa

ELISA, WB, IP

Human; other species not tested.

MAPE antibody; OIP 4 antibody; OIP4 antibody; Opa interacting protein 4 antibody; PRAME antibody

Rabbit IgG

This antibody was obtained by immunization of PRAME recombinant protein (Accession Number: NM_001291716). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The PRAME (preferentially expressed antigen of melanoma) gene was previously shown to be overexpressed in ovarian/primary peritoneal serous carcinoma compared with malignant mesothelioma using gene expression arrays. It is considered a melanocyte differentiation antigen which is overexpressed in both solid and hematologic tumors. In normal tissue, a very low level of PRAME expression is found in normal testis, adrenals, ovary and endometrium. A high level of PRAME expression has been reported for several solid tumors, including ovarian cancer, breast cancer, lung cancer and melanomas, medulloblastoma, sarcomas, head and neck cancers, neuroblastoma, renal cancer, and Wilms’ tumor. As a nuclear transcriptional repressor protein, PRAME binds to retinoic acid receptor a, thereby inhibiting retinoic acid induced differentiation, growth arrest, and apoptosis.