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Product Name
PPP2R1A antibody
- Documents
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Description
PPP2R1A Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, A431 cells, HeLa cells, mouse kidney tissue. Positive IHC detected in human kidney tissue, human ovary tumor tissue. Observed molecular weight by Western-blot: 65 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
PPP2R1A antibody; PR65A antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PPP2R1A recombinant protein (Accession Number: NM_014225). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:114097(PPP2R1A antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human kidney using Catalog No:114097(PPP2R1A antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human kidney using Catalog No:114097(PPP2R1A antibody) at dilution of 1:50 (under 40x lens)
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Background
PPP2R1A belongs to the phosphatase 2A regulatory subunit A family. PPP2R1A encodes the α-isoform of the scaffolding subunit of the serine/threonine protein phosphatase 2A (PP2A) holoenzyme. This tumour suppressor complex is involved in growth and survival pathways and PPP2R1A mutations in endometrial high-grade serous carcinomas are a frequent and potentially targetable feature of this disease(PMID: 21381030). The PPP2R1A gene has 86% identity with the PPP2R1B gene(PMID:7681822).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"