Polycystin 2 antibody

Polycystin 2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Polycystin 2 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in human kidney tissue, HEK-293 cells. Positive IP detected in mouse testis tissue, HeLa cells. Observed molecular weight by Western-blot: 109 kDa

ELISA, WB, IP, IHC

Human,Mouse,Rat; other species not tested.

APKD2 antibody; PC2 antibody; PKD2 antibody; PKD4 antibody; Polycystin 2 antibody; Polycystwin antibody; R48321 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_000297). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Polycystin 2 (PKD2), the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease, belongs to the polycystin family. PKD2 is a ~110-kDa six-transmembrane channel protein with cytoplasmic N- and C-termini. This protein functions as a Ca2+-activated intracellular Ca2+ release channel in the endoplasmic reticulum. It is also present in the plasma membrane, where it functions as a nonselective cation channel. In addition, PKD2 expression has been documented in the primary cilium of kidney epithelial cells, where it is believed to have an essential role in mediating Ca2+ entry in response to flow rate changes, suggesting that it may be part of a mechanosensing machinery residing in the primary cilium. (PMID: 16135816; 10497221)