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Product Name
PMS1 antibody
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Description
PMS1 Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma.
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Tested applications
ELISA, IHC
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
PMS1 antibody; PMSL1 antibody; DKFZp781M0253 antibody; hPMS1 antibody; FLJ98259 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PMS1 recombinant protein (Accession Number: BC008410). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:114029(PMS1 antibody) at dilution of 1:100 (under 10x lens)
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Background
The multiple eukaryotic homologs of the bacterial MutL mismatch repair protein are implicated along with MutS homologs in maintaining genomic integrity during DNA replication and recombination [PMID:16612326]. DNA mismatch repair (MMR) corrects replication errors that would otherwise lead to mutations and, potentially, various forms of cancer. Among several proteins required for eukaryotic MMR, MutLα is a heterodimer comprised of Mlh1 and PMS1 [PMID:19115045]. PMS1 contains an N-terminal domain (NTD) and C-terminal domain (CTD) ,which separated by a flexible linker. Dimerization occurs between the CTDs and the CTD of PMS1 houses a strand-specific endonuclease that is necessary for MMR [PMID:17951253].
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