PLEKHA1 antibody

PLEKHA1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PLEKHA1 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in human placenta tissue, Jurkat cells. Observed molecular weight by Western-blot: 46 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

PLEKHA1 antibody; TAPP 1 antibody; TAPP1 antibody

Rabbit IgG

This antibody was obtained by immunization of PLEKHA1 recombinant protein (Accession Number: XM_017016481). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Pleckstrin homology (PH) domain is commonly found in eukaryotic signaling proteins and possesses multiple functions including the abilities to bind inositol phosphates and various proteins. The tandem PH domain containing protein-1 (TAPP1) or PH domain containing-family A (phosphoinositide binding specific) member 1 (PLEKHA1), interacts strongly and specifically with phosphatidylinositol 3,4-trisphosphate [PtdIns(3,4)P(2)], which is one of the immediate breakdown products of PtdIns(3,4,5) P (3) and functions as a signalling molecule in insulin- and growth-factor-stimulated pathways. TAPP1 is also associated with the protein- tyrosine-phosphatase-like protein-1 (PTPL1 also known as FAP-1) and maintains PTPL1 in cytoplasm. By binding to PtdIns(3,4) P (2) and PTPL1, TAPP1 may regulate the membrane localization of PTPL1."