PINK1 antibody

PINK1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

PINK1 Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue. Positive WB detected in HeLa cells, 293 cells, Jurkat cells, mouse liver tissue. Observed molecular weight by Western-blot: 65 kDa, 45 kDa

ELISA, WB, IHC

Human, Mouse; other species not tested.

BRPK antibody; FLJ27236 antibody; PARK6 antibody; PINK1 antibody; PTEN induced putative kinase 1 antibody

Rabbit IgG

This antibody was obtained by immunization of PINK1 recombinant protein (Accession Number: NM_032409). Purification method: Antigen Affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

PINK1 is a mitochondrial serine/threonine-protein kinase that protects cells from stress-induced mitochondrial dysfunction. The precursor of PINK1 (65 kDa) is synthesized in the cytosol and is imported into the outer membrane of mitochondria. PINK1 is further transferred into the inner membrane where it is cleaved into a 52 kDa mature form. The half life of the mature form of PINK1 is very short and it was proposed that the proteasome is involved in its degradation (PMID: 23472196). The gene of PINK1 maps to chromosome 1p36.12. Two alternatively spliced variants exist, the shorter isoform (30 kDa) produced by alternative splicing. Mutations in the PINK1 gene cause autosomal recessive early-onset Parkinson's disease.