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Product Name
PI3K p110(beta) antibody
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Description
PI3K p110(beta) Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue, human testis tissue. Positive WB detected in HeLa cells, HepG2 cells. Observed molecular weight by Western-blot: 110 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
DKFZp779K1237 antibody; p110 BETA antibody; PI3 kinase subunit beta antibody; PI3K antibody; PI3K beta antibody; PI3K p110(beta) antibody; PI3Kbeta antibody; PI3KCB antibody; PIK3C1 antibody; PIK3CB antibody; PtdIns 3 kinase subunit beta antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PI3K p110(beta) recombinant protein (Accession Number: XM_047448308). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113872(PIK3CB antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:113872(PIK3CB antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:113872(PIK3CB antibody) at dilution of 1:50 (under 40x lens)
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Background
PIK3CB(phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform) is also named as PIK3C1, PI3K-beta, p110beta. The gene encodes a 1070 amino acid protein which belongs to the PI3/PI4-kinase family. Phosphoinositide 3-kinases (PI3Ks) have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. The class I PI3 kinases are heterodimers composed of 110 kDa catalytic subunits that associate with regulatory adaptor proteins. Four class I catalytic subunits have been identified, PIK3CA (p110α), PIK3CB (p110β), PIK3CD (p110δ) and PIK3CG (p110γ)(PMID:19177002). This antibody is specific to PIK3CB.
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