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Product Name
PEX7 antibody
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Description
PEX7 Rabbit Polyclonal antibody. Positive WB detected in MDA-MB-453s cells. Observed molecular weight by Western-blot: 34 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Peroxin 7 antibody; PEX7 antibody; PTS2 receptor antibody; PTS2R antibody; RCDP1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of PEX7 recombinant protein (Accession Number: NM_000288). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with Catalog No:113732(PEX7 antibody) at dilution of 1:800
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Background
PEX7, also known as peroxisomal targeting signal 2 (PTS2) receptor, is one member of peroxins (PEXs) which are proteins required for peroxisome assembly. PEX5 and PEX7 function as receptors that recognize PTS1- and PTS2- containing proteins, respectively. PEX7 plays an essential role in peroxisomal protein import by binding to the N-terminal PTS2-type peroxisomal targeting signal. PEX7 defects are associated with peroxisome biogenesis disorder complementation group 11 (PBD-CG11), rhizomelic chondrodysplasia punctata type 1 (RCDP1) and Refsum disease.
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References
- Mizuno Y, Ninomiya Y, Nakachi Y. Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS genetics. 9(2):e1003286. 2013.
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