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PDP2 antibody

Cat.#: 113634

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Product Information

  • Product Name
    PDP2 antibody
  • Documents
  • Description
    PDP2 Rabbit Polyclonal antibody. Positive WB detected in mouse skeletal muscle tissue, HeLa cells, mouse kidney tissue. Positive IHC detected in mouse brain tissue, human lymphoma tissue. Observed molecular weight by Western-blot: 53 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    KIAA1348 antibody; PDP 2 antibody; PDP2 antibody; PDPC 2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PDP2 recombinant protein (Accession Number: NM_001329933). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:113634(PDP2 antibody) at dilution of 1:300

    mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:113634(PDP2 antibody) at dilution of 1:300

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:113634(PDP2 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:113634(PDP2 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:113634(PDP2 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:113634(PDP2 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    PDP2, is the Ca2+-insensitive isoform of pyruvate dehydrogenase phosphataseis and found in liver and adipose tissue. In adipose tissue,insulin reduces the concentration dependence of PDP2 activity for Mg2+(PMID:12676647).It catalyzes the dephosphorylation and concomitant reactivation of the mitochondrial pyruvate dehydrogenase multienzyme complex.It can be detected the mature (52 kDa) and the immature (60 kDa) bands in western blot.
  • References
    • Ma X, Li C, Sun L. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature communications. 5:5212. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"