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PCM1 antibody

Cat.#: 113741

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Product Information

  • Product Name
    PCM1 antibody
  • Documents
  • Description
    PCM1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HT-1080 cells, NIH/3T3 cells. Positive IP detected in HeLa cells. Positive IHC detected in human tonsillitis tissue. Observed molecular weight by Western-blot: 260-270 kDa
  • Tested applications
    ELISA, WB, IP, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    hPCM 1 antibody; PCM 1 antibody; PCM1 antibody; pericentriolar material 1 antibody; PTC4 antibody
  • Immunogen
    Human PCM1 Recombinant protein (GST tag)
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of PCM1 recombinant protein (Accession Number: NM_001352660). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113741(PCM1 antibody) at dilution of 1:500

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113741(PCM1 antibody) at dilution of 1:500

    IP result of anti-PCM1 (Catalog No:113741 for IP and Detection) with HeLa cells.

    IP result of anti-PCM1 (Catalog No:113741 for IP and Detection) with HeLa cells.

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:113741(PCM1 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:113741(PCM1 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:113741(PCM1 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:113741(PCM1 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    Pericentriolar material 1 (PCM1) is a component of centriolar satellites, which are electron dense granules scattered around centrosomes (PMID: 10579718). PCM1 is required for centrosome assembly and function. It acts as a scaffold to target several proteins to the centrosome in a dynein motor-dependent manner and regulate microtubular dynamics (PMID:18762586; 12403812). It is also involved in the biogenesis of cilia (PMID: 18772192). Chromosomal aberrations involving PCM1 gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. (PMID: 10980597; 16091753; 15805263; 16424865).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"