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PACS2-Specific antibody

Cat.#: 113477

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Product Information

  • Product Name
    PACS2-Specific antibody
  • Documents
  • Description
    PACS2-Specific Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, human brain tissue, human heart tissue, mouse heart tissue. Positive IF detected in MCF-7 cells. Observed molecular weight by Western-blot: 116 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FLJ25488 antibody; KIAA0602 antibody; PACS 2 antibody; PACS1 like protein antibody; PACS1L antibody; PACS2 antibody; PACS-2 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_015197). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IF: 1:10-1:100

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113477(PACS2-Specific antibody) at dilution of 1:600

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113477(PACS2-Specific antibody) at dilution of 1:600

    Immunofluorescent analysis of MCF-7 cells using Catalog No:113477(PACS2-Specific Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of MCF-7 cells using Catalog No:113477(PACS2-Specific Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    PACS2, also named PACS1L or KIAA0602, is one of PACS (phosphofurin acidic cluster sorting) proteins which are one such family of multifunctional membrane traffic regulators that mediate organ homoeostasis and have important roles in diverse pathologies and disease states. PACS2 is a multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, ER homeostasis, and apoptosis. PACS2 may be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
  • References
    • Dombernowsky SL, Samsøe-Petersen J, Petersen CH. The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. Nature communications. 6:7518. 2015.
    • Hamasaki M, Furuta N, Matsuda A. Autophagosomes form at ER-mitochondria contact sites. Nature. 495(7441):389-93. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"