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Product Name
P2RY6 antibody
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Description
P2RY6 Rabbit Polyclonal antibody. Positive WB detected in A549 cells, human spleen tissue. Observed molecular weight by Western-blot: 45kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
P2RY6 antibody; P2Y6 antibody; P2Y purinOCeptor 6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of P2RY6 recombinant protein (Accession Number: NM_001277206). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:113547(P2RY6 antibody) at dilution of 1:300
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Background
Nucleotides, the structural subunits of the nucleic acids, are also important extracellular signaling molecules. P2 receptors are a family of cell surface receptors that mediate a wide variety of physiologic effects in response to extracellular nucleotides. These receptors fall into two classes: P2X receptors, which are ligand-gated ion channels that mediate calcium and potassium fluxes in response to ATP, and P2Y receptors, which are G protein-coupled receptors (GPCRs). P2RY6 is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. (PMID: 8670200; 21724990)
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References
- there was a problem with your PMID, try again.
- Takai E, Tsukimoto M, Harada H, Kojima S. Involvement of P2Y6 receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes. Radiation research. 175(3):358-66. 2011.
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