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OXA1L antibody

Cat.#: 113523

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Product Information

  • Product Name
    OXA1L antibody
  • Documents
  • Description
    OXA1L Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, L02 cells, NIH/3T3 cells. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 42 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Hsa antibody; OXA1 like protein antibody; OXA1Hs antibody; OXA1L antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of OXA1L recombinant protein (Accession Number: NM_005015). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IF: 1:20-1:200

  • Validations

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:113523(OXA1L antibody) at dilution of 1:800

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:113523(OXA1L antibody) at dilution of 1:800

    Immunofluorescent analysis of (10% Formaldehyde) fixed HepG2 cells using Catalog No:113523(OXA1L Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of (10% Formaldehyde) fixed HepG2 cells using Catalog No:113523(OXA1L Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    Oxa1 is a member of the conserved Oxa1/YidC/Alb3 protein family and is required for cytochrome c oxidase assembly. The Oxa1 protein was initially identified in yeast proteins involved in the biogenesis of the mitochondrial respiratory chain complexes. It locates in the inner membrane of mitochondria and may be involved in mediating the insertion of proteins from the matrix into the inner membrane.
  • References
    • Mishra P, Carelli V, Manfredi G, Chan DC. Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Cell metabolism. 19(4):630-41. 2014.
    • Chan NC, den Besten W, Sweredoski MJ, Hess S, Deshaies RJ, Chan DC. Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2. The Journal of biological chemistry. 289(28):19789-98. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"