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Product Name
Orail-L2 antibody
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Description
Orail-L2 Rabbit Polyclonal antibody. Positive WB detected in human spleen tissue. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 44 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_032790). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
human spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:113419(Orail-L2 antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using Catalog No:113419(Orail-L2 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using Catalog No:113419(Orail-L2 Antibody) at dilution of 1:50 (under 40x lens)
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Background
Store-operated calcium channels (Socs) play essential functions in various physiological processes. Orai1 (also named CRACM1) is a critical molecular component of Socs. Orai1 protein is a 35-45 kDa plasma membrane protein with 4 transmembrane domains. Human patients with a severe combinaed immunodeficiency (SCID) syndrome possess point mutations in Orai1 gene. This antibody may be used to block the ion currents mediated by Orai1.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"