OAS2 antibody

OAS2 antibody

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• Material Safety Data Sheets (MSDS)

OAS2 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human colon tissue, human liver cancer tissue. Positive IF detected in HepG2 cells. Positive WB detected in Jurkat cells, HL-60 cells, human liver tissue, mouse lung tissue. Positive IP detected in Jurkat cells. Observed molecular weight by Western-blot: 66-71 kDa

ELISA, WB, IHC, IF, IP

Human, Mouse; other species not tested.

(2 5)oligo(A) synthase 2 antibody; 2 5 oligoadenylate synthase 2 antibody; 2 5A synthase 2 antibody; OAS2 antibody; p69 OAS / p71 OAS antibody; p69OAS / p71OAS antibody

Rabbit IgG

This antibody was obtained by immunization of OAS2 recombinant protein (Accession Number: NM_002535). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS2, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). OAS2 is also named as p69 OAS / p71 OAS. It has 3 isoforms(71/69/20 kDa) produced by alternative splicing. The OAS2 isozymes are 69–71 kDa and form dimers(PMID:17765707). Glycosylation is essential for its activity(PMID:9880569). Constitutive expression of the 69-kDa form of the OAS2 protein in human cells inhibited the replication of encephalomyocarditis virus (EMCV) but not that of VSV, Sendai virus, or reovirus(PMID:16501108). This antibody is specific to isoform p71 and isoform p69 of OAS2.

• Grammatikos AP, Ghosh D, Devlin A, Kyttaris VC, Tsokos GC. Spleen tyrosine kinase (Syk) regulates systemic lupus erythematosus (SLE) T cell signaling. PloS one. 8(8):e74550. 2013.