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Product Name
NUP153 antibody
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Description
NUP153 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, A431 cells. Positive IP detected in K-562 cells. Observed molecular weight by Western-blot: 153 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
153 kDa nucleoporin antibody; HNUP153 antibody; N153 antibody; nucleoporin 153kDa antibody; Nucleoporin Nup153 antibody; NUP153 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of NUP153 recombinant protein (Accession Number: NM_005124). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
K-562 cells were subjected to SDS PAGE followed by western blot with Catalog No:113375(NUP153 antibody) at dilution of 1:500
IP Result of anti-NUP153 (IP:Catalog No:113375, 4ug; Detection:Catalog No:113375 1:500) with K-562 cells lysate 3600ug.
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Background
NUP153 is an FG-repeat containing NUP, contains a high-affinity site for importin-β, localizes on the nucleoplasmic face of the nuclear pore and is required for assembly of the nuclear basket and import of a subset of nuclear proteins [PMID:18845677]. NUP153 also facilitates nuclear export of mRNA and ribonucleoprotein particles and may have additional functions within the nucleus [PMID:16195343]. The 53BP1-NUP153/importin-β pathway as an important aspect of the DDR network add to an emerging evidence of subcellular trafficking as an integral part of genome surveillance [PMID:22075984].
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"