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Product Name
NR2F6 antibody
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Description
NR2F6 Mouse Monoclonal antibody. Positive IHC detected in human kidney tissue. Positive WB detected in MCF-7 cells, MCF7 cells. Observed molecular weight by Western-blot: 42 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
EAR 2 antibody; EAR2 antibody; ERBAL2 antibody; NR2F6 antibody; V erbA related protein 2 antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of NR2F6 recombinant protein (Accession Number: NM_005234). Purification method: .
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Clonality
Monoclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human kidney using Catalog No:107337(NR2F6 antibody) at dilution of 1:50 (under 40x lens)
MCF-7 cells were subjected to SDS PAGE followed by western blot with Catalog No:107337(NR2F6 Antibody) at dilution of 1:1000
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Background
NR2F6 belongs to NR2F subfamily members, which have their roles in the regulation of neurogenesis, organogenesis, and cellular differentiation during embryonic development [PMID:15875024]. NR2F6 acts as transcription factor by binding to a TGACCT direct-repeat motif and has been established in controlling facets of central nervous system (CNS) [12690040]. It is a nuclear attenuator that directly interferes with DNA binding of NF-AT and, subsequently, transcriptional activity of the NF-AT-dependent IL-17 expression. Otherwise, NR2F6 negatively interfered with transcriptional cytokine responses and acted as a barrier against autoimmunity [PMID:18701084].
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"