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Product Name
NR2B antibody
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Description
NR2B Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IF detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 166kd
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Tested applications
ELISA, WB, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
GRIN2B antibody; hNR3 antibody; NMDAR2B antibody; NR2B antibody; NR3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_000834). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IF: 1:10-1:100
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113234(GRIN2B antibody) at dilution of 1:400
Immunofluorescent analysis of SH-SY5Y cells using Catalog No:113234(GRIN2B Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
GRIN2B, also named as NMDAR2B, NR3 and NR2B, belongs to the glutamate-gated ion channel (TC 1.A.10) family. GRIN2B is NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. It is mediated by glycine. The antibody recognizes the C-term of GRIN2B.
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References
- Geng D, Kang L, Su Y. Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons. Neurochemistry international. 63(4):283-90. 2013.
- Deng L, Li G, Rao B, Li H. Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration. Brain research. 1622:186-95. 2015.
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