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NKX2-5 antibody

Cat.#: 113204

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Product Information

  • Product Name
    NKX2-5 antibody
  • Documents
  • Description
    NKX2-5 Rabbit Polyclonal antibody. Positive WB detected in human heart tissue. Positive IHC detected in human brain tissue. Observed molecular weight by Western-blot: 37kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    Cardiac specific homeobox antibody; CHNG5 antibody; CSX antibody; CSX1 antibody; Homeobox protein CSX antibody; Homeobox protein Nkx 2.5 antibody; NKX2 5 antibody; NKX2.5 antibody; NKX2-5 antibody; NKX2E antibody; NKX4 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of NKX2-5 recombinant protein (Accession Number: NM_004387). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113204(NKX2-5 antibody) at dilution of 1:1200

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:113204(NKX2-5 antibody) at dilution of 1:1200

    Immunohistochemical of paraffin-embedded human brain using Catalog No:113204(NKX2-5 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:113204(NKX2-5 antibody) at dilution of 1:100 (under 10x lens)

  • Background
    Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development [PMID: 7665173]. NKX2-5 encoded by homeobox-containing genes that implicated in commitment to and/or differentiation of the myocardial lineage, and acts as a transcriptional activator of ANF in cooperation with GATA4. During embryonic development, NKX2-5 plays pivotal roles in specifying cardiac progenitors, cardiac morphogenesis, cardiomyocyte differentiation and conduction system development [PMID: 22824467].
  • References
    • Nie J, Jiang M, Zhang X. Post-transcriptional Regulation of Nkx2-5 by RHAU in Heart Development. Cell reports. 13(4):723-32. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"