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Product Name
NHLRC1 antibody
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Description
NHLRC1 Rabbit Polyclonal antibody. Positive WB detected in L02 cells. Positive IHC detected in human heart. Observed molecular weight by Western-blot: 45-47kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
human; other species not tested.
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Alternative names
NHLRC1 antibody; EPM2A antibody; bA204B7.2 antibody; NHL repeat containing 1 antibody; EPM2B antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of NHLRC1 recombinant protein (Accession Number: NM_198586). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
L02 cells were subjected to SDS PAGE followed by western blot with Catalog No:113178(NHLRC1 antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human heart using Catalog No:113178(NHLRC1 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human heart using Catalog No:113178(NHLRC1 antibody) at dilution of 1:50 (under 40x lens)
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Background
NHLRC1(NHL repeat-containing protein 1) is also named as Malin,EPM2B. It is predicted to encode a 42.3-kDa (395amino acid) protein, malin, containing a detectable zinc-binding RING finger and six NHL-repeat domains(PMID:12958597).It can suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS).Defects in NHLRC1 are a cause of progressive myoclonic epilepsy type 2 (EPM2).This antibody is specific to NHLRC1.
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