NFKB2,p52,p100-Specific antibody

NFKB2,p52,p100-Specific antibody

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NFKB2,p52,p100-Specific Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human brain tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human spleen tissue. Positive WB detected in A431 cells, HeLa cells, MCF-7 cells, mouse heart tissue. Observed molecular weight by Western-blot: 52/100kd

ELISA, IHC, WB

Human, Mouse; other species not tested.

DNA binding factor KBF2 antibody; H2TF1 antibody; LYT 10 antibody; LYT10 antibody; NFKB2 antibody; NFKB2 antibody; p100 antibody; NFKB2 antibody; p52 antibody; p100 antibody; Oncogene Lyt 10 antibody; p100 antibody; p52 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_001077494). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. P52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. This antibody can bind both p52 and p100 isoforms of NFKB2.