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Neuropilin 1 antibody

Cat.#: 107330

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Product Information

  • Product Name
    Neuropilin 1 antibody
  • Documents
  • Description
    Neuropilin 1 Mouse Monoclonal antibody. Positive WB detected in Human Blood. Positive IHC detected in human placenta tissue, human gliomas tissue. Positive IF detected in human embronic stem cells. Observed molecular weight by Western-blot: 103 kDa
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    BDCA4 antibody; CD304 antibody; DKFZp686A03134 antibody; DKFZp781F1414 antibody; neuropilin 1 antibody; NRP antibody; NRP1 antibody; VEGF165R antibody
  • Isotype
    Mouse IgG
  • Preparation
    This antibody was obtained by immunization of Neuropilin 1 recombinant protein (Accession Number: NM_001024629). Purification method: Caprylic acid/ammonium sulfate precipitation.
  • Clonality
    Monoclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • Validations

    human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:107330(NRP1 antibody) at dilution of 1:500

    human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:107330(NRP1 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human placenta using Catalog No:107330(NRP1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human placenta using Catalog No:107330(NRP1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human placenta using Catalog No:107330(NRP1 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human placenta using Catalog No:107330(NRP1 antibody) at dilution of 1:50 (under 40x lens)

    Confocal immunofluorescent analysis of human embronic stem cells with Catalog No:107330 at dilution of 1:100. DAPI was used to stain the cell nuclei (blue) at a concentration of 1ug/ml. This photo is the merge of PE and DAPI. (40X)

    Confocal immunofluorescent analysis of human embronic stem cells with Catalog No:107330 at dilution of 1:100. DAPI was used to stain the cell nuclei (blue) at a concentration of 1ug/ml. This photo is the merge of PE and DAPI. (40X)

  • Background
    Neuropilin-1 (NRP1) is a transmembrane glycoprotein expressed by endothelial, dendritic, and regulatory T cells, as well as several other normal cell types and malignant tumor cells. NRP1 was first identified as a semaphorin (SEMA) receptor, involved in axonal guidance in embryonic development. NRP1 was also shown to act as a receptor for vascular endothelial growth factor (VEGF) and a promoter of angiogenesis through its interaction with VEGF-A165 (and other VEGFs) and the receptor tyrosine kinase (RTK) VEGF-R2. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.
  • References
    • Liu C, Wang Z, Wang Y, Gu W. MiR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1. Molecular and cellular biochemistry. 398(1-2):115-22. 2015.
    • Saad S, Dharmapatni AA, Crotti TN. Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss. Acta biomaterialia. 30:311-8. 2016.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"