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Product Name
NEIL3 antibody
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Description
NEIL3 Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells, A431 cells, human skin tissue, mouse skin tissue. Observed molecular weight by Western-blot: 62-68 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
DNA glycosylase FPG2 antibody; DNA glycosylase/AP lyase Neil3 antibody; Endonuclease 8 like 3 antibody; Endonuclease VIII like 3 antibody; FGP2 antibody; FLJ10858 antibody; FPG2 antibody; hFPG2 antibody; hNEI3 antibody; Nei like protein 3 antibody; NEI3 antibody; NEIL3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of NEIL3 recombinant protein (Accession Number: NM_018248). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:113100(NEIL3 antibody) at dilution of 1:500
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Background
NEIL3 belongs to the FPG family. It is a functional DNA glycosylase in vitro and in vivo. NEIL3 plays a role in repairing FapyG in vivo. (PMID:20185759) NEIL3 has AP lyase activity specific for single-stranded DNA.(PMID:19170771). NEIL3 is specifically expressed in brain areas where neurogenesis takes place during development and that its expression is tightly regulated both temporally and spatially. (PMID:19426544) Read more about this antibody on the blog: http://blog.ptglab.com/index.php/proteintechs-anti-neil3-antibody-used-investigate-mechanisms-of-dna-repair/?preview=true
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References
- Neurauter CG, Luna L, Bjørås M. Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK-MAP kinase pathway. DNA repair. 11(4):401-9. 2012.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"