Nectin 2 antibody

Nectin 2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Nectin 2 Rabbit Polyclonal antibody. Positive FC detected in MCF-7 cells. Positive WB detected in mouse kidney tissue, 3T3-L1 cells, mouse heart tissue. Observed molecular weight by Western-blot: 64 kDa

ELISA, WB, FC

Human, Mouse; other species not tested.

CD112 antibody; Herpes virus entry mediator B antibody; Herpesvirus entry mediator B antibody; HVEB antibody; Nectin 2 antibody; PRR2 antibody; PVRL2 antibody; PVRR2 antibody

Rabbit IgG

This antibody was obtained by immunization of Nectin 2 recombinant protein (Accession Number: NM_002856). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Poliovirus receptor-related 2 (herpesvirus entry mediator B) (PVRL2, synonyms: HVEB, PRR2, CD112, PVRR2) is an adhesion molecule widely expressed in cell lines of different lineages, including hematopoietic, neuronal, endothelial and epithelial cells. CD112 belongs to a new family of immunoglobulin-like molecules that includes four members (CD111 , CD112, PRR3 and CD155) sharing an ectodomain made of three Ig domains, of V, C, C types. CD112 is expressed in the myelo-monocytic and megakaryocytic hematopoietic lineages and the function in hematopoiesis is currently unknown. CD112 is an intercellular homophilic adhesion. CD112 localizes specifically at adherents junctions via its cytoplasmic interaction with the scaffold F-actin binding protein afadin. This interaction is mediated by a sequence located to the C terminal ends of both isoforms of CD112 (A/ExYV) and the PDZ domain of afadin. This sequence is also found in CD112 and PRR3 and represents a specific consensus in the family, which is also named nectin family. Disruption of the murine CD112 gene leads to infertility of male mice with morphologically aberrant spermatozoa. CD112 mediates entry of some alphaherpesvirus mutants (also named HveB) via its V domain. CD112 is involved in cell to cell spreading of viruses

• Dudak A, Kim J, Cheong B, Federoff HJ, Lim ST. Membrane palmitoylated proteins regulate trafficking and processing of nectins. European journal of cell biology. 90(5):365-75. 2011.