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Product Name
MRPL3 antibody
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Description
MRPL3 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, A431 cells, HepG2 cells. Positive IHC detected in human cervical cancer tissue, human liver cancer tissue. Observed molecular weight by Western-blot: 39kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
L3mt antibody; MRL3 antibody; MRP L3 antibody; MRPL3 antibody; RPML3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MRPL3 recombinant protein (Accession Number: NM_007208). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:112822(MRPL3 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:112822(MRPL3 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human cervical cancer using Catalog No:112822(MRPL3 antibody) at dilution of 1:100 (under 40x lens)
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Background
MRPL3, also named as 39S ribosomal protein L3, mitochondrial or RPML3, is a 348 amino acid protein, which belongs to the ribosomal protein L3P family. MRPL3 localizes in the Mitochondrion and has an association with combined oxidative phosphorylation deficiency 9. MRPL3 plays role in the mitochondrial proteins biosynthesis and ribosomal structure and biogenesis.
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References
- Galmiche L, Serre V, Beinat M. Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy. Human mutation. 32(11):1225-31. 2011.
- Serre V, Rozanska A, Beinat M. Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency. Biochimica et biophysica acta. 1832(8):1304-12. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"