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Product Name
Mouse Serpind1/Hcf2/Hcii (His tag) recombinant protein
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Description
SerpinD1, also known as heparin cofactor II(HC-II), is a member of Serpin superfamily of the serine proteinase inhibitors. It is a single chain glycoprotein with a size of 66.5 kDa and is secreted from hepatocytes. HC-II acts as a thrombin inhibitor in the coagulation cascade, in a glycosaminoglycan-dependent pathway using the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. This serpin belongs to multiple member group V2 of vertebrate serpin classification. It has been suggested that HC-II is a predictor of decreased atherosclerosis in the elderly and protective against atherosclerosis in mice. HCII can used as a predictive biomarker and therapeutic target for atherosclerosis.
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Protein name
serine (or cysteine) peptidase inhibitor, clade D, member 1(Serpind1)
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Protein short names
Hcf2; Hcii
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Uniprot ID
P49182
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Serpind1/Hcf2/Hcii Glu24-Ser478 is expressed with a 6His tag at the C-terminus.
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Protein Species
Mouse
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Purity
>95% as determined by SDS-PAGE.
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Validations
Mouse Serpind1/Hcf2/Hcii (His tag) recombinant protein
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