Human MOB1B / MOBKL1A (GST Tag) recombinant protein

Human MOB1B / MOBKL1A (GST Tag) recombinant protein

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Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

MOB kinase activator 1B

1110003E08RIK; B230364F10; MOB1B; MOB1 HOMOLOG 1A; MATS2; MOB1; MPS ONE BINDER KINASE ACTIVATOR-LIKE 1A; AU015450; MOBKL1A; MOB KINASE ACTIVATOR 1B; MOB4A

Q7L9L4

MOB1B; MOB4A; MOBKL1A

E. coli

A DNA sequence encoding the human MOBKL1A (Q7L9L4) (Met1-Arg216) was fused with the GST tag at the N-terminus.

Human

The recombinant human MOBKL1A /GST chimera consists of 450 amino acids and has a predicted molecular mass of 52.3 kDa. It migrates as an approximately 43-48 KDa band in SDS-PAGE under reducing conditions.

> 85 % as determined by SDS-PAGE