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Product Name
MNS1 antibody
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Description
MNS1 Rabbit Polyclonal antibody. Positive WB detected in rat testis tissue. Positive IHC detected in human testis tissue. Observed molecular weight by Western-blot: 55-60 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FLJ11222 antibody; FLJ26051 antibody; meiosis nuclear structural 1 antibody; MNS1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MNS1 recombinant protein (Accession Number: NM_018365). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
rat testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:112717(MNS1 Antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:112717(MNS1 Antibody) at dilution of 1:50 (under 40x lens)
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Background
Meiosis-specific nuclear structural 1 (MNS1), is abundantly expressed in post-meiotic spermatids and is required for proper flagellar formation and function. Male mice deficient in MNS1 display decreased sperm production and are sterile because their sperm are immotile. The microtubules and ODFs of the flagella are disrupted, resulting in abnormal, short sperm tails. In addition, MNS1 is also required for motile ciliary functions.
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