MLK4 antibody

MLK4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MLK4 Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue. Positive IF detected in C6 cells. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 53 kDa

ELISA, WB, IF, IHC

Human, Mouse, Rat; other species not tested.

dJ862P8.3 antibody; KIAA1804 antibody; mixed lineage kinase 4 antibody; MLK4 antibody; RP5 862P8.2 antibody

Rabbit IgG

This antibody was obtained by immunization of MLK4 recombinant protein (Accession Number: NM_032435). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MLK4 belongs to the MAP kinase kinase kinase subfamily. The MLK family members are characterized by the presence of signature sequences ofSer/Thr and Tyr kinases within their catalytic domain. The MLK1-4 contains an aminoterminal Src-Homology (SH3) domain, followed by the kinase domain, a leucine-zipper region, and a Cdc42/Rac-interactive binding (CRIB) motif. MLK4 expressed in two splicing variants, MLK4α and MLK4β. The difference of these two isoforms is located in their C-terminal portion. The negative effect of MLK4 on LPS-induced ERK and JNK activation could be very important in controlling the level of cytokine expression, and thus maintaining the balance of inflammatory responses.(PMID:21602844). This protein has 3 isoforms produced by alternative splicing with the molecular weight of 63 kDa, 113 kDa, 53 kDa.