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Product Name
MIP-3-beta antibody
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Description
MIP-3-beta Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma tissue. Positive IF detected in A549 cells. Positive WB detected in A549 cells, HepG2 cells. Observed molecular weight by Western-blot: 12 kDa
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Tested applications
ELISA, WB, IHC, IF
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Species reactivity
Human; other species not tested.
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Alternative names
Beta chemokine exodus 3 antibody; C C motif chemokine 19 antibody; CCL19 antibody; CK beta 11 antibody; CKb11 antibody; EBI1 ligand chemokine antibody; ELC antibody; MIP 3 beta antibody; MIP 3b antibody; MIP3B antibody; MIP-3-beta antibody; SCYA19 antibody; Small inducible cytokine A19 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MIP-3-beta recombinant protein (Accession Number: NM_006274). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:112627(MIP3β antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:112627(MIP3β antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:112627(MIP3β antibody) at dilution of 1:100 (under 40x lens)
Immunofluorescent analysis of A549 cells using Catalog No:112627(MIP3β Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
CCL19, also known as MIP-3β, is one of several CC cytokine genes clustered on the p-arm of chromosome 9. CCL19 may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.
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References
- Perros F, Dorfmüller P, Montani D. Pulmonary lymphoid neogenesis in idiopathic pulmonary arterial hypertension. American journal of respiratory and critical care medicine. 185(3):311-21. 2012.
- Mathes AL, Christmann RB, Stifano G. Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin. Annals of the rheumatic diseases. 73(10):1864-72. 2014.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"