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Product Name
MIER3 antibody
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Description
MIER3 Rabbit Polyclonal antibody. Positive WB detected in mouse uterus tissue. Observed molecular weight by Western-blot: 55kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
MIER3 antibody; FLJ35954 antibody; DKFZp781I1119 antibody; DKFZp781G1119 antibody; Mi er3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MIER3 recombinant protein (Accession Number: XM_047416839). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse uterus tissue were subjected to SDS PAGE followed by western blot with Catalog No:112618(MIER3 antibody) at dilution of 1:300
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Background
The mesoderm induction early response (MIER) protein family is known as fibroblast growth factor (FGF)-regulated immediate-early protein family. Activated by FGF, MIER proteins may have a pivotal role in FGF-regulated cellular activities, indicating a potential influence in the progression of certain cancers [PMID:15117948]. MIER3 localizes to the nucleus and primarily functions as a transcriptional repressor. Rat mammary carcinoma susceptibility 1b (Mcs1b) is a quantitative trait locus on RN02 that confers decreased susceptibility when Copenhagen (COP)-resistant alleles are introgressed into a Wistar Furth (WF)-susceptible genome. MIER3 is a candidate Mcs1b gene [PMID:22993404].
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References
- Chen SW, Liu CC, Yen HC. Detection of suppressed maturation of the human COQ5 protein in the mitochondria following mitochondrial uncoupling by an antibody recognizing both precursor and mature forms of COQ5. Mitochondrion. 13(2):143-52. 2013.
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