MED12 antibody

MED12 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MED12 Rabbit Polyclonal antibody. Positive WB detected in mouse liver tissue. Observed molecular weight by Western-blot: 230kd

ELISA, WB

Human,Mouse,Rat; other species not tested.

ARC240 antibody; CAG repeat protein 45 antibody; CAGH45 antibody; FGS1 antibody; HOPA antibody; KIAA0192 antibody; MED12 antibody; mediator complex subunit 12 antibody; OKS antibody; OPA containing protein antibody; OPA1 antibody; TNRC11 antibody; TRAP230 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_005120). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Mediator of RNA polymerase II transcription subunit 12 (MED12), also named Activator-recruited cofactor 240 kDa component, Thyroid hormone receptor-associated protein complex 230 kDa component. MED12 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Molecular weight of MED12 is about 240kd.This antibody is specific to MED12.

• Bertsch E, Qiang W, Zhang Q. MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 27(8):1144-53. 2014.