MCM4 antibody

MCM4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MCM4 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, HL-60 cells, human liver tissue. Positive IP detected in HEK-293 cells. Observed molecular weight by Western-blot: 97 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

CDC21 antibody; CDC21 homolog antibody; CDC54 antibody; hCdc21 antibody; MCM4 antibody; P1 CDC21 antibody

Rabbit IgG

This antibody was obtained by immunization of MCM4 recombinant protein (Accession Number: NM_005914). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

DNA replication licensing factor MCM4 (MCM4), also named Cdc21, acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of MCM4 protein.

• Valle BL, D'Souza T, Becker KG. Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells. PloS one. 8(4):e61836. 2013.