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MCCC2 antibody

Cat.#: 112544

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Product Information

  • Product Name
    MCCC2 antibody
  • Documents
  • Description
    MCCC2 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer. Positive WB detected in human liver tissue. Observed molecular weight by Western-blot: 61kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    MCCC2 antibody; MCCase subunit beta antibody; MCCB antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MCCC2 recombinant protein (Accession Number: BC014897). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:112544(MCCC2 antibody) at dilution of 1:400

    human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:112544(MCCC2 antibody) at dilution of 1:400

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:112544(MCCC2 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human pancreas cancer using Catalog No:112544(MCCC2 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    MCCC2(Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial) is also named as MCCB and belongs to the AccD/PCCB family. The putative 563-amino acid polypeptide has a calculated molecular mass of 61 kD and contains an N-terminal mitochondrial targeting sequence(PMID:11181649). It catalyzes carboxylation of 3 methylcrotonyl COA to form 3 methylglutaconyl-COA and is probably a dodecamer composed of six biotin-containing alpha subunits and six beta subunits. Defects in MCCC2 are the cause of methylcrotonoyl-CoA carboxylase 2 deficiency (MCC2D).
  • References
    • Pang J, Liu WP, Liu XP. Profiling protein markers associated with lymph node metastasis in prostate cancer by DIGE-based proteomics analysis. Journal of proteome research. 9(1):216-26. 2010.
    • Dai J, Zhan C, Xu W. Nicotine elevates sperm motility and induces Pfn1 promoter hypomethylation in mouse testis. Andrology. 3(5):967-78. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"