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Product Name
MBNL3 antibody
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Description
MBNL3 Rabbit Polyclonal antibody. Positive WB detected in mouse skeletal muscle tissue. Positive IHC detected in human skeletal muscle tissue. Observed molecular weight by Western-blot: 38 kDa
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Tested applications
ELISA, IHC, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
CHCR antibody; Cys3His CCG1 required protein antibody; FLJ11316 antibody; MBLX antibody; MBLX39 antibody; MBNL3 antibody; MBXL antibody; Muscleblind like protein 3 antibody; Protein HCHCR antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MBNL3 recombinant protein (Accession Number: NM_001170704). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:112508(MBNL3 Antibody) at dilution of 1:600
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:112508(MBNL3 Antibody) at dilution of 1:50 (under 40x lens)
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Background
MBNL3, also named as Muscleblind-like protein 3 or Cys3His CCG1-required protein, is a 354 amino acid protein, which contains four C3H1-type zinc fingers and belongs to the muscleblind family. MBNL3 localizes in the nucleus and is highly expressed in the placenta. MBNL3 mediates pre-mRNA alternative splicing regulation and plays a role in myotonic dystrophy pathophysiology. MBNL3 could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
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