MAPKAPK2 antibody

MAPKAPK2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MAPKAPK2 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human breast cancer tissue. Positive IF detected in HeLa cells. Positive WB detected in HeLa cells, A549 cells, mouse colon tissue, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 47-50 kDa

ELISA, WB, IHC, IF

Human, Mouse; other species not tested.

MAPKAP kinase 2 antibody; MAPKAPK 2 antibody; MAPKAPK2 antibody; MK2 antibody

Rabbit IgG

This antibody was obtained by immunization of MAPKAPK2 recombinant protein (Accession Number: NM_032960). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MAPKAPK2(mitogen-activated protein kinase-activated protein kinase 2) is also named as MK2, MAPKAP-K2, MK-2 and belongs to the CAMK Ser/Thr protein kinase family. MAPKAPK2, one of several kinases directly phosphorylated and activated by p38 MAPK, plays a central role in the inflammatory response and is in the nucleus of unstimulated cells and moves rapidly to the cytoplasm after stimulation(PMID:12171911). It is also involved in many other cellular processes including stress responses, nuclear export, gene expression regulation and cell proliferation. Multiple residues of MAPKAPK2 are generally phosphorylated in vivo in response to stress, but only 4 residues(Thr25, Thr222, Ser272, and Thr334) are phosphorylated by p38 MAPK in vitro(PMID:22351694). It has 2 isoforms produced by alternative splicing and the range of the molecular weight is 42-60 kDa according to the references(PMID:10666409; 11328854;8995385).