MAPKAP1 antibody

MAPKAP1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MAPKAP1 Rabbit Polyclonal antibody. Positive WB detected in mouse skeletal muscle tissue, HeLa cells. Positive IHC detected in human heart. Observed molecular weight by Western-blot: 37-42kd,55kd

ELISA, WB, IHC

human, mouse, rat; other species not tested.

MAPKAP1 antibody; JC310 antibody; SIN1 antibody; SAPK interacting protein 1 antibody; mSIN1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_024117). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MAPKAP1, also named as MIP1 and SIN1, belongs to the SIN1 family. It is a subunit of mTORC2 which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. It inhibits HRAS and KRAS signaling. MAPKAP1 enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. The antibody is specific to MAPKAP1. The antibody can recognize all the isoform of MAPKAP1.