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Product Name
MAdCAM1 antibody
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Description
MAdCAM1 Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue, human small intestine tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
hMAdCAM 1 antibody; MACAM1 antibody; MAdCAM1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MAdCAM1 recombinant protein (Accession Number: BC142629). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:112370(MADCAM1 Antibody) at dilution of 1:200 (under 40x lens).
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:112370(MADCAM1 Antibody) at dilution of 1:200 (under 40x lens).
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Background
Lymphocyte recirculation through different organs is thought to be regulated by adhesion molecules ("homing receptors") recognizing tissue-specific vascular addressins on endothelium (PMID: 7511642). The mucosal vascular addressin, MAdCAM1, is an immunoglobulin superfamily adhesion receptor for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria (PMID: 7687523). MAdCAM1 can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"