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Product Name
LSR antibody
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Description
LSR Rabbit Polyclonal antibody. Positive FC detected in HepG2 cells. Positive WB detected in rat liver tissue, L02 cells, mouse liver tissue. Observed molecular weight by Western-blot: 56 kDa, 68 kDa
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Tested applications
ELISA, WB, FC
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Species reactivity
Human,Rat, Mouse; other species not tested.
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Alternative names
ILDR3 antibody; LISCH antibody; LISCH7 antibody; LSR antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of LSR recombinant protein (Accession Number: BC004381). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
rat liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:112354(LSR antibody) at dilution of 1:1000
1X10^6 HepG2 cells were stained with .2ug LSR antibody (Catalog No:112354, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
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Background
LSR (lipolysis stimulated lipoprotein receptor) is a lipoprotein receptor primarily expressed in the liver and activated by free fatty acids (PMID: 10224102). This remnant receptor binds both apoB- and apoE-containing lipoproteins and displays greastest affinity for TG-rich lipoproteins. Distribution of LSR causes embryonic lethality in mice, indicating that the expression of LSR is critical for liver and embryonic development (PMID: 15265030). Investigations show that LSR is a multimer consisting of α subunit (68 kDa) and β subunit (56 kDa) associated through disulfide bridges (PMID: 10224102; 19188430; 18644789).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"