Cart 2

LSM1 antibody

Cat.#: 112345

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    LSM1 antibody
  • Documents
  • Description
    LSM1 Rabbit Polyclonal antibody. Positive IHC detected in human prostate cancer tissue. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, mouse kidney tissue. Observed molecular weight by Western-blot: 18-20 kDa
  • Tested applications
    ELISA, IHC, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Cancer assOCiated Sm like antibody; CASM antibody; LSM1 antibody; Small nuclear ribonuclear CaSm antibody; YJL124C antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of LSM1 recombinant protein (Accession Number: NM_014462). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:112345(LSM1 antibody) at dilution of 1:600

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:112345(LSM1 antibody) at dilution of 1:600

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:112345(LSM1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:112345(LSM1 antibody) at dilution of 1:100 (under 10x lens)

    IP Result of anti-LSM1 (IP:Catalog No:112345, 4ug; Detection:Catalog No:112345 1:300) with HeLa cells lysate 2000ug.

    IP Result of anti-LSM1 (IP:Catalog No:112345, 4ug; Detection:Catalog No:112345 1:300) with HeLa cells lysate 2000ug.

  • Background
    Lsm1 is a component of the Lsm1-7 complex involved in cytoplasmic mRNA degradation. Lsm1 is a key subunit that determines the RNA-binding properties of this complex. The normal RNA-binding activity of this complex is crucial for mRNA decay and 3'-end protection in vivo and requires the intact Sm-domain of Lsm1. LSM1 localizes to cytoplasmic processing bodies (P bodies) involved in mRNA storage, processing, regulation, and degradation and is required for P-body formation. LSM1 proteins facilitate the formation of U4/U6 RNA duplexes in vitro and may play a role in U4/U6 snRNP formation.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"