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Product Name
LSAMP antibody
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Description
LSAMP Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, mouse brain tissue. Observed molecular weight by Western-blot: 64-68 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
FLJ54658 antibody; IgLON family member 3 antibody; IGLON3 antibody; LAMP antibody; LSAMP antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of LSAMP recombinant protein (Accession Number: NM_002338). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:112343(LSAMP antibody) at dilution of 1:300
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Background
LSAMP, also known as LAMP, is a 64-68 kDa heavily glycosylated neural cell adhesion molecule expressed on the neuronal dendrites and somata (PMID: 1688937; 8666243). LSAMP is a member of the IgLON family. The amino acid sequence of LSAMP is highly conserved among species. Human LSAMP share 99% amino acid sequence identity with rodent LSAMP. The impact of LSAMP protein on neurite outgrowth and neuronal connectivity has been established in a wide spectrum of psychiatric disorders in humans (PMID: 26136648). In mice, lack of LSAMP protein seemingly leads to a deterioration in the ability to adapt to novel stressful environments and stimuli (PMID: 22155487).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"