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Product Name
LRAT antibody
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Description
LRAT Rabbit Polyclonal antibody. Positive WB detected in Y79 cells, mouse testis tissue. Observed molecular weight by Western-blot: 26 kDa,50-54 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
LRAT antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of LRAT recombinant protein (Accession Number: NM_004744). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:112313(LRAT antibody) at dilution of 1:500
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Background
LRAT belongs to the H-rev107 family. LRAT transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, LRAT monomers(26kd) interact in membranes and form functional homodimers (50-54kd) through protein-protein interactions and disulfide bond formation.Defects in LRAT are a cause of severe early-onset retinal dystrophy (RD). This antibody was generated against the internal residues of human LRAT. It is predicted to detect endogenous LRAT.
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