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Product Name
LGP2 antibody
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Description
LGP2 Rabbit Polyclonal antibody. Positive IP detected in mouse liver tissue. Positive WB detected in HEK-293 cells. Positive IHC detected in human breast cancer tissue. Observed molecular weight by Western-blot: 77 kDa
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Tested applications
ELISA, IHC, IP, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
D11LGP2 antibody; D11lgp2e antibody; DHX58 antibody; LGP2 antibody; Protein D11Lgp2 homolog antibody; RIG I like receptor LGP2 antibody; RLR antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of LGP2 recombinant protein (Accession Number: XM_047436724). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IP: 1:200-1:1000
IHC: 1:10-1:100
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Validations
IP Result of anti-DHX58 (IP:Catalog No:112209, 3ug; Detection:Catalog No:112209 1:300) with mouse liver tissue lysate 6000ug.
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:112209(DHX58 antibody) at dilution of 1:10 (under 10x lens)
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:112209(DHX58 Antibody) at dilution of 1:300
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Background
DHX58(Probable ATP-dependent RNA helicase DHX58) is also named as D11LGP2E, LGP2 and belongs to the RLR subfamily. DHX58, originally identified as a highly expressed gene in mammary tumors, is another cytoplasmic DEX(D/H)-box helicase that can recognize RNA(PMID: 18411269). It acts as a positive, but not negative, regulator of RIG-I– and MDA5-dependent recognition of RNA virus infection and plays a pivotal role in antiviral responses in vivo(PMID:20080593).
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References
- Furr SR, Chauhan VS, Sterka D, Grdzelishvili V, Marriott I. Characterization of retinoic acid-inducible gene-I expression in primary murine glia following exposure to vesicular stomatitis virus. Journal of neurovirology. 14(6):503-13. 2008.
- Chopy D, Pothlichet J, Lafage M. Ambivalent role of the innate immune response in rabies virus pathogenesis. Journal of virology. 85(13):6657-68. 2011.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"