LGALS3BP antibody

Cat.#: 112204

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Product Information

  • Product Name
    LGALS3BP antibody
  • Documents
  • Description
    LGALS3BP Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, mouse brain tissue. Positive IF detected in HepG2 cells. Positive IHC detected in human breast cancer tissue, human skin tissue. Observed molecular weight by Western-blot: 65-70 kDa
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    90K antibody; BTBD17B antibody; Galectin 3 binding protein antibody; LGALS3BP antibody; M2BP antibody; Mac 2 binding protein antibody; MAC 2 BP antibody; MAC2BP antibody; Tumor assOCiated antigen 90K antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of LGALS3BP recombinant protein (Accession Number: NM_005567). Purification method: Antigen Affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • Validations

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:112204(LGALS3BP antibody) at dilution of 1:1000

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:112204(LGALS3BP antibody) at dilution of 1:1000

    Immunohistochemistry of paraffin-embedded human breast cancer slide using Catalog No:112204(LGALS3BP Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human breast cancer slide using Catalog No:112204(LGALS3BP Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human breast cancer slide using Catalog No:112204(LGALS3BP Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human breast cancer slide using Catalog No:112204(LGALS3BP Antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of HepG2 cells using Catalog No:112204(LGALS3BP Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of HepG2 cells using Catalog No:112204(LGALS3BP Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP is a widely expressed, secreted galectin. It has been found elevated in the serum of patients with various types of breast, lung, colorectal, ovary, and endometrial cancer, and in those infected by the human immunodeficiency virus (HIV). High expression levels of LGALS3BP are associated with a shorter survival, the occurrence of metastasis or a reduced response to chemotherapy. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Immunoblotting showed that LGALS3BP is likely contained in breast milk, serum, semen, saliva, urine, and tears.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"