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Product Name
LCA5 antibody
- Documents
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Description
LCA5 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 80 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
C6orf152 antibody; LCA5 antibody; Leber congenital amaurosis 5 antibody; Lebercilin antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of LCA5 recombinant protein (Accession Number: NM_001122769). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:112167(LCA5 Antibody) at dilution of 1:300
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Background
LCA5 (Leber congenital amaurosis 5), also named as C6orf152 or Lebercilin, is a 697 amino acids protein. LCA5 is widely expressed at the microtubules, centrosome, and primary cilia. Recent study showed that LCA5 was involved in the cause of congenital and early-onset retinal dystrophies (PMID: 24144451). The MW of this protein is 80 kDa, and this antibody specially recognises the 80 kDa protein.
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References
- Karlstetter M, Sorusch N, Caramoy A. Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration. Human molecular genetics. 23(19):5197-210. 2014.
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